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Drugs used to treat diabetes, such as glimepiride, and other sulfonylurea drugs can also occasionally interact with alcohol and cause dizziness, nausea, flushing (redness of the face), and extremely low blood glucose levels, Elder said.

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Differential effects of rosiglitazone and metformin on adipose tissue distribution and glucose uptake in type 2 diabetic subjects.

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Adverse reactions (excluding hypoglycemia, which is discussed separately below) commonly associated with Symlin when coadministered with a fixed dose of insulin in the 26- to 52-week, placebo-controlled trials in patients with type 1 diabetes and patients with type 2 diabetes on mealtime insulin are presented in Table 1 and Table 2, respectively.

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These lists are not complete and there are many other medicines that can increase or decrease the effects of glimepiride and pioglitazone on lowering your blood sugar.

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Adequate circulating insulin is a prerequisite for TZD activity () and should be accounted for before initiating therapy, otherwise there is a risk that the full effect of TZDs cannot be achieved.

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Repaglinide is metabolized via oxidative metabolism and glucuronidation, with no dosage adjustments needed in patients with renal insufficiency; however, prolonged exposure to the medication may occur with hepatic impairment.

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Address correspondence to Shoichiro Nagasaka, MD, Division of Endocrinology and Metabolism, Jichi Medical School, Yakushiji 3311-1, Minamikawachi, Tochigi 329-0498, Japan.

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