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Dihydrotestosterone-dependent cell functions depend on the availability of weak androgens, their conversion to more potent androgens via the action of 5α-reductase, low enzymatic activity of androgen inactivating enzymes, and functionally active AR present in high numbers.
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It was estimated that 20 percent of the participants would die during the study, that 5 percent would decline to undergo a prostate biopsy, and that 15 percent would be lost to follow-up.
For the treatment of benign prostatic hyperplasia, the dose is 5 mg once daily.
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Physical examinations, including digital rectal examinations, and routine hematologic and serum-chemistry tests were performed yearly.
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The adverse experience profiles in the 1-year, placebo-controlled, Phase III BPH studies and the 5-year open extensions with PROSCAR 5 mg and PLESS were similar.
In these BPH studies, finasteride 5 mg tablets did not appear to alter the rate of prostate cancer detection, and the overall incidence of prostate cancer was not significantly different in patients treated with finasteride 5 mg tablets or placebo.
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Testosterone promotes DNA damage response under oxidative stress in prostate cancer cell lines.
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It can lead to death, especially if treatment surgery and antibiotics is not rapidly available.
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These trials reported improvements in urinary frequency, urgency, nocturnal micturition, patient perceptions of bladder conditions, and the International Prostate Symptom Score (IPSS) compared with AAB monotherapy.
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In spite of the fact that man's baldness (thinning hair and baldness on the top) can be called many other factors - such as tension, diseases, drugs which accept, influence to toxic substances and a large number of others if started to lose hair between age 25 and 45 - possibilities, have man's baldness.
MantelHaenszel test was used to analyze categorical variables, with data stratified according to center.
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Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.
Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect.
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