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Current work aims to reliably elicit pattern MMN with reduced variance in onset.

THC effects on noise and the relationship between noise and psychosis-like effects were independent of signal power.

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Methods: RNA was extracted from whole blood using the PAXgene extraction kit (QIagen) and whole-genome transcriptional profiling was performed using Illumina Human HT-12 microarrays.

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In adults, the prevalence of lithium-induced hypothyroid-ism generally increases with longer duration of therapy--about 20% of women and 5% of men are affected with hypothyroidism after 10 years of continuous treatment.

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Corresponding to others, flexible rather than fixed dosage was found to effect dropout in second-generation and not first-generation arms.

Table 13 enumerates the incidence, rounded to the nearest percent, of treatment-emergent adverse reactions that occurred during acute therapy with intramuscular ziprasidone in 1% or more of patients.

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Conclusion: Using a virtual reality-based progressive ratio task coupled with fMRI, this study investigated the neural correlates of effort valuation impairments in schizophrenia.

Bipolar disorder, or manic-depressive illness, is a disorder that causes unusual and extreme mood changes.

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Conclusion: These findings demonstrate that γ oscillation dysfunction is present in CHR as well as FES, and worsens over time.

The risk is greatest with clozapine and olanzapine, followed by quetiapine and risperidone, and then followed by aripiprazole and ziprasidone.

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CVLT performance and common variants was run (1000 iterations) in the CNP control sample and multiple cut-points (SNPs present in 700, 800, and 900 of 1000 associations) were used to calculate CVLT polygenic scores.

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Conclusion: The findings suggest that many family and child variables are predictive of psychopathology in general, including PE, whereas HyperToM is specifically associated to PE.

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Hyperglycemia, in some cases extreme and associated with ketoacidosis or hyperosmolar coma or death, has been reported in patients treated with atypical antipsychotics.

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In a longitudinal study of 871 New Zealand children, using bioelectrical impedance to calculate percentage body fat, Blair et al.

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Background: APA is a risk factor for schizophrenia (Sz) and bipolar disorder (BP).

The atypical antipsychotic, ziprasidone, may antagonize the effect of the dopamine agonist, bromocriptine.

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Mixed effects models for meta-analysis were used to identify design features that effected dropout and develop formulae to derive expected dropout rates based on trial design features, and these assigned a pivotal role to duration.

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Clozapine improved the glucose uptake and production and release of lactate, without altering GLUT and MCT.

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Finally, we observed strong correlations between impulsivity phenotype polygenic scores and schizophrenia risk scores calculated using variants identified by the Psychiatric Genomics Consortium in a large case-control sample (SWG, 2014).

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Suicidal attempts in bipolar disorder: results from an observational study (EMBLEM).

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Symptoms often appear within a few weeks of beginning the antipsychotic or increasing the dosage, but can also arise after long-term stable use.

Methods: MRI DTI data were acquired in 63 FEP patients and in 52 healthy control (HC) subjects.

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Background: Strategic remediation approaches highlight instruction and provide experience of evaluation of strategy efficiency during therapy which builds metacognitive knowledge and metacognitive regulation.

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Results: Although there were significant effects of Risk Group, and Time effects, we observed no significant Time x Group effect.

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Antipsychotic drugs and risks of myocardial infarction: a self-controlled case series study.

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Methods: To distinguish among these possibilities, we used the following pre- and postsynaptic markers of dendritic spines: Vglut1, specific to excitatory terminals of cortical origin; spinophilin, protein phosphatase 1 binding protein that is highly concentrated in spines; PSD95 and gephyrin, scaffolding proteins for excitatory and inhibitory synapses, respectively.

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In general, these studies report significant weight gain and increase in BMI with risperidone use, and variable elevation in prolactin levels.

During the initial assessment and the follow-up, both positive and negative symptoms of psychosis can be assessed using the 30 item Positive and Negative Symptom Scale (PANSS).

Change in 6-VAS-D Scores During Each Phase.

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Conclusion: These findings converge on hippocampal GABAergic interneuron pathology in psychotic disorders, and may help generate novel hypotheses for diagnostics and drug development.

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The Clinical Global Impression scale for use in BPD patients (CGI-BPD) was the primary outcome measure, and other scales and self-reports related to affect, behavior, psychosis, general psychopathology domains and clinical safety were included.

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Recent research suggests that dysregulation of NMDA receptor function via availability of receptor co-agonists, which bind at the allosteric glycine modulatory site (GMS), may play a role in the pathopyhsiology of both schizophrenia and drug addiction.

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Results: Multi-level linear regression models were estimated to examine the associations between negative affect, emotion regulation strategies and delusional thoughts.

Personality and bipolar disorder: dissecting state and trait associations between mood and personality.

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Methods: Twenty-one ROSz, 10 demographically similar healthy controls (RO-Ctrl), 24 CSz, and 20 demographically similar healthy controls (C-Ctrl) completed two social cognitive tasks: 1) a low-level task of emotion perception from biological motion (Emo Bio), and 2) a high-level task of mental state attributions involving detection of lies and sarcasm (TASIT).

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Background: Efficient coupling between task-positive brain networks and the default-mode network promotes performance in working memory and other aspects of cognition.

Ziprasidone at a dose of 20 mg twice daily did not affect the pharmacokinetics of concomitantly administered oral contraceptives, ethinyl estradiol (0.

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This pathological interaction, induced by RAGE, is a potential trigger of PVI and PNN impairments observed in schizophrenia.

For CGI-I, the baseline value was based on the comparison with screening, and subsequent weekly assessments were based on comparisons with baseline.

Assessment of the effect of age at onset on linkage to bipolar disorder: evidence on chromosomes 18p and 21q.

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This presentation gives an overview of pre-clinical and clinical data illustrating, first, the mechanisms underlying transduction of peripheral immune signals to the brain, and secondly, the relevance of the immune-brain communication to schizophrenia phenotypes.

Intramuscular: Ziprasidone intramuscular has not been systematically evaluated in elderly patients or in patients with hepatic or renal impairment.

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Rates of MetS were the highest in patients older than 38 years (86%), prescribed clozapine or olanzapine (73%) and in those treated with two or more antipsychotic medications (67%).

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