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Methods: RNA was extracted from whole blood using the PAXgene extraction kit (QIagen) and whole-genome transcriptional profiling was performed using Illumina Human HT-12 microarrays.

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In adults, the prevalence of lithium-induced hypothyroid-ism generally increases with longer duration of therapy--about 20% of women and 5% of men are affected with hypothyroidism after 10 years of continuous treatment.

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Corresponding to others, flexible rather than fixed dosage was found to effect dropout in second-generation and not first-generation arms.

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Conclusion: Using a virtual reality-based progressive ratio task coupled with fMRI, this study investigated the neural correlates of effort valuation impairments in schizophrenia.

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Conclusion: These findings demonstrate that γ oscillation dysfunction is present in CHR as well as FES, and worsens over time.

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CVLT performance and common variants was run (1000 iterations) in the CNP control sample and multiple cut-points (SNPs present in 700, 800, and 900 of 1000 associations) were used to calculate CVLT polygenic scores.

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Conclusion: The findings suggest that many family and child variables are predictive of psychopathology in general, including PE, whereas HyperToM is specifically associated to PE.

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Methods: MRI DTI data were acquired in 63 FEP patients and in 52 healthy control (HC) subjects.

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Results: Although there were significant effects of Risk Group, and Time effects, we observed no significant Time x Group effect.

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Methods: To distinguish among these possibilities, we used the following pre- and postsynaptic markers of dendritic spines: Vglut1, specific to excitatory terminals of cortical origin; spinophilin, protein phosphatase 1 binding protein that is highly concentrated in spines; PSD95 and gephyrin, scaffolding proteins for excitatory and inhibitory synapses, respectively.

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During the initial assessment and the follow-up, both positive and negative symptoms of psychosis can be assessed using the 30 item Positive and Negative Symptom Scale (PANSS).

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The Clinical Global Impression scale for use in BPD patients (CGI-BPD) was the primary outcome measure, and other scales and self-reports related to affect, behavior, psychosis, general psychopathology domains and clinical safety were included.

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Recent research suggests that dysregulation of NMDA receptor function via availability of receptor co-agonists, which bind at the allosteric glycine modulatory site (GMS), may play a role in the pathopyhsiology of both schizophrenia and drug addiction.

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Personality and bipolar disorder: dissecting state and trait associations between mood and personality.

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Methods: Twenty-one ROSz, 10 demographically similar healthy controls (RO-Ctrl), 24 CSz, and 20 demographically similar healthy controls (C-Ctrl) completed two social cognitive tasks: 1) a low-level task of emotion perception from biological motion (Emo Bio), and 2) a high-level task of mental state attributions involving detection of lies and sarcasm (TASIT).

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Background: Efficient coupling between task-positive brain networks and the default-mode network promotes performance in working memory and other aspects of cognition.

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This pathological interaction, induced by RAGE, is a potential trigger of PVI and PNN impairments observed in schizophrenia.

For CGI-I, the baseline value was based on the comparison with screening, and subsequent weekly assessments were based on comparisons with baseline.

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This presentation gives an overview of pre-clinical and clinical data illustrating, first, the mechanisms underlying transduction of peripheral immune signals to the brain, and secondly, the relevance of the immune-brain communication to schizophrenia phenotypes.

Intramuscular: Ziprasidone intramuscular has not been systematically evaluated in elderly patients or in patients with hepatic or renal impairment.

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