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These transporters control dopaminergic transmission by spatial and temporal buffering, rendering the molecule an imaging target in diseases affecting the dopaminergic nigrostriatal pathway.

Typically, patients develop considerable cognitive dysfunction (disordered thinking) within the first 4 - 5 years of the onset of psychotic symptoms.

There are three strategies designed to improve levodopa-induced dyskinesias: 1) reduce the dosage of levodopa, 2) use drugs known to ameliorate dyskinesias, and 3) surgery.

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Since younger patients seem to be at a higher risk of levodopa-related motor complications, delaying levodopa therapy seems to be a prudent practice at least in this population of PD patients.

Like depression, anxiety has been reported in up to 40% of PD patients (; ); similarly, anxiety may precede the appearance of motor symptoms by many years, and usually before onset of depression ().

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Thus, with the possible exception of spasticity in multiple sclerosis, there is little reason to recommend additional clinical trials of marijuana or cannabinoids for movement disorders, the IOM study team concluded.

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The baseline characteristics of the patients were summarised using descriptive statistics.

Drug induced parkinsonism tends to remain at its presenting level, not progress like Parkinson's disease.

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Reaction formation is the avoidance of anxiety through behavior and attitudes that are the opposite of repressed impulses and drives.

Exposure to the weed killer paraquat or to the fungicides maneb or mancozeb is particularly toxic, increasing the risk for PD about 2-fold.

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The mechanism of action of entacapone is related to its ability to inhibit COMT and alter plasma pharmacokinetics of levodopa.

These forms are related to your Medicare Advantage plan (Cigna-HealthSpring Advantage plan).

The benefit of adding folic acid to the drug regimen of patients taking levodopa has been discussed.

Primidone may be preferred, because of the exercise intolerance associated with high-dose beta blockade.

Although this review has attempted to highlight the most recent advances in the treatment of PD, it is important to note that new treatments are not necessarily better than the established conventional therapy and that the treatment options must be individualized and tailored to the needs of each individual patient.

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